Metabolic engineering Saccharomyces cerevisiae for de novo production of the sesquiterpenoid (+)-nootkatone.

ABSTRACT:

Background

(+)-Nootkatone is a highly valued sesquiterpenoid compound, exhibiting a typical grapefruit aroma and various desired biological activities for use as aromatics and pharmaceuticals. The high commercial demand of (+)-nootkatone is predominately met by chemical synthesis, which entails the use of environmentally harmful reagents. Efficient synthesis of (+)-nootkatone via biotechnological approaches is thus urgently needed to satisfy its industrial demand. However, there are only a limited number of studies that report the de novo synthesis of (+)-nootkatone from simple carbon sources in microbial cell factories, and with relatively low yield.

Results

As the direct precursor of (+)-nootkatone biosynthesis, (+)-valencene was first produced in large quantities in Sacch

SUBMITTER: Meng X 

PROVIDER: S-EPMC6998195 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature