Cancer/testis antigens expression during cultivation of melanoma and soft tissue sarcoma cells.

ABSTRACT:

Background

Autologous dendritic cells (DC) loaded with tumor-associated antigens (TAAs) are a promising approach for anticancer immunotherapy. Polyantigen lysates appear to be an excellent source of TAAs for loading onto the patient's dendritic cells. Cancer/testis antigens (CTA) are expressed by a wide range of tumors, but are minimally expressed on normal tissues, and could serve as a universal target for immunotherapy. However, CTA expression levels can vary significantly in patients with the same tumor type. We proposed that patients who do not respond to DC-based therapy may have distinct features of the CTA expression profile on tumor cells.

Patients and methods

We compared the gene expression of the principal families CTA in 22 melanoma and 27 soft tissue and bone sar

SUBMITTER: Danilova A 

PROVIDER: S-EPMC6998350 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature