Sex differences in the evolution of left ventricle remodeling in rats with severe volume overload.

ABSTRACT: BACKGROUND:Aortic valve regurgitation (AR) results in left ventricle (LV) volume overload (VO) leading to its dilation and hypertrophy (H). We study a rat model of severe AR induced by puncturing one or two leaflets using a catheter. Most of our studies were conducted in male animals. Recently, we started investigating if sex dimorphism existed in the AR rat model. We observed that AR females developed as much LVH as males but morphological remodeling differences were present. A head-to-head comparison of LV morphological and functional changes had never been performed in AR males (M) and females (F) using the latest modalities in cardiac imaging by echocardiography. METHODS:We performed a longitudinal study to evaluate the development of LV hypertrophy caused by chronic AR in male and fem

SUBMITTER: Walsh-Wilkinson E 

PROVIDER: S-EPMC6998357 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature