Associations of noise kurtosis, genetic variations in NOX3 and lifestyle factors with noise-induced hearing loss.

ABSTRACT:

Background

Noise-induced hearing loss (NIHL) is a complex disease caused by environmental and genetic risk factors. This study was to explore the association of noise kurtosis, triphosphopyridine nucleotide oxidase 3 (NOX3) and lifestyles with NIHL.

Methods

This case-control study included 307 patients with NIHL and 307 matched control individuals from Zhejiang province of China. General characteristics, noise exposure data, the exfoliated cells of the oral mucosa, and lifestyle details of individuals were collected. The kompetitive allele specific polymerase chain reaction (KASP) method was used to analyze the genotypes of three single nucleotide polymorphisms (SNPs) of NOX3.

Results

People who exposed to complex noise had a higher risk of NIHL than those exposed to

SUBMITTER: Zhao T 

PROVIDER: S-EPMC6998835 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature