Respiratory Syncytial Virus Disease Severity Is Associated with Distinct CD8⁺ T-Cell Profiles.

ABSTRACT: Rationale: Respiratory syncytial virus (RSV) causes significant morbidity and mortality in infants worldwide. Although T-helper type 2 (Th2) cell pathology is implicated in severe disease, the mechanisms underlying the development of immunopathology are incompletely understood.Objectives: We aimed to identify local immune responses associated with severe RSV in infants. Our hypothesis was that disease severity would correlate with enhanced Th2 cellular responses.Methods: Nasal aspirates were collected from infants hospitalized with severe (admitted to the pediatric ICU) or moderate (maintained in the general ward) RSV disease at 5 to 9 days after enrollment. The immune response was investigated by evaluating T-lymphocyte cellularity, cytokine concentration, and viral l

SUBMITTER: Siefker DT 

PROVIDER: S-EPMC6999109 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature