A porous medium-chain-length poly(3-hydroxyalkanoates)/hydroxyapatite composite as scaffold for bone tissue engineering.

ABSTRACT: Polyhydroxyalkanoates (PHA) are hydrophobic biopolymers with huge potential for biomedical applications due to their biocompatibility, excellent mechanical properties and biodegradability. A porous composite scaffold made of medium-chain-length poly(3-hydroxyalkanoates) (mcl-PHA) and hydroxyapatite (HA) was fabricated using particulate leaching technique and NaCl as a porogen. Different percentages of HA loading was investigated that would support the growth of osteoblast cells. Ultrasonic irradiation was applied to facilitate the dispersion of HA particles into the mcl-PHA matrix. The different P(3HO-co-3HHX)/HA composites were investigated using field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD) and energy dispersive X-ray analysis (EDXA). The scaffolds were fou

SUBMITTER: Ansari NF 

PROVIDER: S-EPMC6999529 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature