Pathogenic role of exosomes and microRNAs in HPV-mediated inflammation and cervical cancer: A review.

ABSTRACT: Cervical cancer (CC) is the fourth most common cause of cancer death in women. The most important risk factor for the development of CC is cervical infection with human papilloma virus (HPV). Inflammation is a protective strategy that is triggered by the host against pathogens such as viral infections that acts rapidly to activate the innate immune response. Inflammation is beneficial if it is brief and well controlled; however, if the inflammation is excessive or it becomes of chronic duration, it can produce detrimental effects. HPV proteins are involved, both directly and indirectly, in the development of chronic inflammation, which is a causal factor in the development of CC. However, other factors may also have a potential role in stimulating chronic inflammation. MicroRNAs (miRNAs) (

SUBMITTER: Sadri Nahand J 

PROVIDER: S-EPMC6999596 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature