Topology-dependent, bifurcated mitochondrial quality control under starvation.

ABSTRACT: Selective elimination of mitochondria by autophagy is a critical strategy for a variety of physiological processes, including development, cell-fate determination and stress response. Although several mechanisms have been identified as responsible for selective degradation of mitochondria, such as the PINK1-PRKN/PARKIN- and receptor-dependent pathways, aspects of the mechanisms and particularly the principles underlying the selection process of mitochondria remain obscure. Here, we addressed a new selection strategy in which the selective elimination of mitochondria is dependent on organellar topology. We found that populations of mitochondria undergo different topological transformations under serum starvation, either swelling or forming donut shapes. Swollen mitochondria are associated w

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC6999642 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature