A Novel Prognostic Index Based on Alternative Splicing in Papillary Renal Cell Carcinoma.

ABSTRACT:

Background

Papillary renal cell carcinoma (pRCC) is a heterogeneous multifocal or isolated tumor with an invasive phenotype. Previous studies presented that alternative splicing, as a crucial posttranscriptional regulator in gene expression, is associated with tumorigenesis. However, the association between alternative splicing and pRCC has not been clarified.

Methods

The RNA sequencing data and clinical information were downloaded from The Cancer Genome Atlas database and mRNA splicing profiles from TCGASpliceSeq. The percent spliced in data of alternative splicing merged with survival information was firstly calculated by univariate Cox regression analysis to screen for survival-associated alternative splicing events, and survival-associated alternative splicing events wer

SUBMITTER: Wu Z 

PROVIDER: S-EPMC6999693 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature