Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity.

ABSTRACT: The red-crowned crane (Grus japonensis) is an endangered, large-bodied crane native to East Asia. It is a traditional symbol of longevity and its long lifespan has been confirmed both in captivity and in the wild. Lifespan in birds is known to be positively correlated with body size and negatively correlated with metabolic rate, though the genetic mechanisms for the red-crowned crane's long lifespan have not previously been investigated. Using whole genome sequencing and comparative evolutionary analyses against the grey-crowned crane and other avian genomes, including the long-lived common ostrich, we identified redcrowned crane candidate genes with known associations with longevity. Among these are positively selected genes in metabolism and immunity pathways (NDUFA5, NDUFA8, N

SUBMITTER: Lee H 

PROVIDER: S-EPMC6999708 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature