Dorsal Amygdala Neurotrophin-3 Decreases Anxious Temperament in Primates.

ABSTRACT:

Background

An early-life anxious temperament (AT) is a risk factor for the development of anxiety, depression, and comorbid substance abuse. We validated a nonhuman primate model of early-life AT and identified the dorsal amygdala as a core component of AT's neural circuit. Here, we combine RNA sequencing, viral-vector gene manipulation, functional brain imaging, and behavioral phenotyping to uncover AT's molecular substrates.

Methods

In response to potential threat, AT and brain metabolism were assessed in 46 young rhesus monkeys. We identified AT-related transcripts using RNA-sequencing data from dorsal amygdala tissue (including central nucleus of the amygdala [Ce] and dorsal regions of the basal nucleus). Based on the results, we overexpressed the neurotrophin-3 gene, NT

SUBMITTER: Fox AS 

PROVIDER: S-EPMC6999854 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature