Blistering1 Modulates Penicillium expansum Virulence Via Vesicle-mediated Protein Secretion.

ABSTRACT: The blue mold fungus, Penicillium expansum, is a postharvest apple pathogen that contributes to food waste by rotting fruit and by producing harmful mycotoxins (e.g. patulin). To identify genes controlling pathogen virulence, a random T-DNA insertional library was created from wild-type P. expansum strain R19. One transformant, T625, had reduced virulence in apples, blistered mycelial hyphae, and a T-DNA insertion that abolished transcription of the single copy locus in which it was inserted. The gene, Blistering1, encodes a protein with a DnaJ domain, but otherwise has little homology outside the Aspergillaceae, a family of fungi known for producing antibiotics, mycotoxins, and cheese. Because protein secretion is critical for these processes and for host infec

SUBMITTER: Jurick WM 

PROVIDER: S-EPMC7000123 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature