Interpersonal life stress, inflammation, and depression in adolescence: Testing Social Signal Transduction Theory of Depression.

ABSTRACT:

Background

Depression rates increase markedly for girls across the adolescent transition, but the social-environmental and biological processes underlying this phenomenon remain unclear. To address this issue, we tested a key hypothesis from Social Signal Transduction Theory of Depression, which posits that individuals who mount stronger inflammatory responses to social stress should exhibit greater increases in depressive symptoms following interpersonal life stress exposure than those who mount weaker inflammatory responses to such stress.

Method

Participants were 116 adolescent girls (M_age  = 14.71) at risk for psychopathology, defined as having a history of mental health concerns (e.g., psychiatric treatment, significant symptoms) over the past 2 years. At bas

SUBMITTER: Slavich GM 

PROVIDER: S-EPMC7000138 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature