Association between Use of Methadone, Other Central Nervous System Depressants, and QTc Interval-Prolonging Medications and Risk of Mortality in a Large Cohort of Women Living with or at Risk for Human Immunodeficiency Virus Infection.

ABSTRACT:

Study objective

To evaluate the association between use of methadone, other central nervous system (CNS) depressants, and QTc interval-prolonging medications and risk of mortality among human immunodeficiency virus (HIV)-infected and at-risk HIV-uninfected women.

Design

Multicenter, prospective, observational cohort study (Women's Interagency HIV Study [WIHS]).

Participants

A total of 4150 women enrolled in the WIHS study between 1994 and 2014 who were infected (3119 women) or not infected (1031 women) with HIV.

Measurements and main results

Data on medication utilization were collected from all study participants via interviewer-administered surveys at 6-month intervals (1994-2014). Mortality was confirmed by National Death Index data. With age defining the ti

SUBMITTER: Tamraz B 

PROVIDER: S-EPMC7000174 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature