Genomic analysis on broiler-associated <i>Clostridium perfringens</i> strains and exploratory caecal microbiome investigation reveals key factors linked to poultry necrotic enteritis.

ABSTRACT:

Background

Clostridium perfringens is a key pathogen in poultry-associated necrotic enteritis (NE). To date there are limited Whole Genome Sequencing based studies describing broiler-associated C. perfringens in healthy and diseased birds. Moreover, changes in the caecal microbiome during NE is currently not well characterised. Thus, the aim of this present study was to investigate C. perfringens virulence factors linked to health and diseased chickens, including identifying putative caecal microbiota signatures associated with NE.

Results

We analysed 88 broiler chicken C. perfringens genomes (representing 66 publicly available genomes and 22 newly sequenced genomes) using different phylogenomics approaches and identified a potential hypervirulent

SUBMITTER: Kiu R 

PROVIDER: S-EPMC7000242 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature