Dysregulation of the splicing machinery is directly associated to aggressiveness of prostate cancer.

ABSTRACT:

Background

Dysregulation of splicing variants (SVs) expression has recently emerged as a novel cancer hallmark. Although the generation of aberrant SVs (e.g. AR-v7/sst5TMD4/etc.) is associated to prostate-cancer (PCa) aggressiveness and/or castration-resistant PCa (CRPC) development, whether the molecular reason behind such phenomena might be linked to a dysregulation of the cellular machinery responsible for the splicing process [spliceosome-components (SCs) and splicing-factors (SFs)] has not been yet explored.

Methods

Expression levels of 43 key SCs and SFs were measured in two cohorts of PCa-samples: 1) Clinically-localized formalin-fixed paraffin-embedded PCa-samples (n = 84), and 2) highly-aggressive freshly-obtained PCa-samples (n = 42).

Findings

A profound dys

SUBMITTER: Jimenez-Vacas JM 

PROVIDER: S-EPMC7000340 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature