Heteroleptic Coordination Environments in Metal-Mediated DNA G-Quadruplexes.

ABSTRACT: The presence of metal centers with often highly conserved coordination environments is crucial for roughly half of all proteins, having structural, regulatory, or enzymatic function. To understand and mimic the function of metallo-enzymes, bioinorganic chemists pursue the challenge of synthesizing model compounds with well-defined, often heteroleptic metal sites. Recently, we reported the design of tailored homoleptic coordination environments for various transition metal cations based on unimolecular DNA G-quadruplex structures, templating the regioselective positioning of imidazole ligandosides L I . Here, we expand this modular system to more complex, heteroleptic coordination environments by combining L I with a new benzoate ligandoside L B within the same oligonucleotide. The modifica

SUBMITTER: Punt PM 

PROVIDER: S-EPMC7000376 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature