Genotypes of HLA, TCF7L2, and FTO as potential modifiers of the association between sweetened beverage consumption and risk of LADA and type 2 diabetes.

ABSTRACT:

Purpose

Sweetened beverage consumption is associated with type 2 diabetes (T2D) and LADA. We investigated to what extent this association is mediated by BMI and whether it is modified by genotypes of HLA, TCF7L2 rs7903146, or FTO rs9939609.

Methods

Swedish case-control data including incident cases of LADA (n = 386) and T2D (n = 1253) with matched population-based controls (n = 1545) was used. We estimated adjusted ORs of diabetes (95% CI) in relation to sweetened beverage intake (per daily 200 mL serving) and genotypes. The impact of BMI was estimated using causal mediation methodology. Associations with HOMA-IR and HOMA-B were explored through linear regression.

Results

Sweetened beverage intake was associated with increased risk of LADA (OR 1.15, 95% CI 1.03-1.29)

SUBMITTER: Lofvenborg JE 

PROVIDER: S-EPMC7000500 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature