Ontology highlight
ABSTRACT:
SUBMITTER: Tuzmen C
PROVIDER: S-EPMC7000558 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Tuzmen Ceren C Cairns Tina M TM Atanasiu Doina D Lou Huan H Saw Wan Ting WT Hall Bonnie L BL Cohen Justus B JB Cohen Gary H GH Glorioso Joseph C JC
Molecular therapy. Methods & clinical development 20200113
Effective oncolytic virotherapy may require systemic delivery, tumor targeting, and resistance to virus-neutralizing (VN) antibodies. Since herpes simplex virus (HSV) glycoprotein D (gD) is the viral attachment/entry protein and predominant VN target, we examined the impact of gD retargeting alone and in combination with alterations in dominant VN epitopes on virus susceptibility to VN antibodies. We compared the binding of a panel of anti-gD monoclonal antibodies (mAbs) that mimic antibody spec ...[more]