Image-Derived Input Functions for Quantification of A₁ Adenosine Receptors Availability in Mice Brains Using PET and [¹⁸F]CPFPX.

ABSTRACT:

Purpose

In vivo imaging for the A₁ adenosine receptors (A₁ARs) with positron emission tomography (PET) using 8-cyclopentyl-3-(3-[¹⁸F]fluoropropyl)-1-propylxan- thine ([¹⁸F]CPFPX) has become an important tool for studying physiological processes quantitatively in mice. However, the measurement of arterial input functions (AIFs) on mice is a method with restricted applicability because of the small total blood volume and the related difficulties in withdrawing blood. Therefore, the aim of this study was to extract an appropriate [¹⁸F]CPFPX image-derived input function (IDIF) from dynamic PET images of mice.

Procedures

In this study, five mice were scanned with [¹⁸F]CPFPX for 60 min. Arterial blood samples

SUBMITTER: He X 

PROVIDER: S-EPMC7000659 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature