Association of the tumour stroma percentage in the preoperative biopsies with lymph node metastasis in colorectal cancer.

ABSTRACT:

Background

Preoperative prediction of lymph node (LN) status is integral to determining the most appropriate treatment strategy for colorectal cancer (CRC). This study aimed to develop and validate a nomogram to predict LN metastasis in CRC preoperatively.

Methods

A total of 530 patients were enrolled and divided into training and validation cohorts. The tumour stroma percentage (TSP) of the preoperative biopsies was assessed. The risk factors for LN metastasis were selected, and a nomogram was constructed subsequently. The performance of the nomogram was assessed by using the AUROC and the calibration curve, and then validated in the validation cohort.

Results

High TSP was significantly associated with LN metastasis in both the training and validation cohorts. Comput

SUBMITTER: Fu M 

PROVIDER: S-EPMC7000705 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature