Clinical relevance of TP53 hotspot mutations in high-grade serous ovarian cancers.

ABSTRACT:

Background

Mutation of TP53 is the most frequent genetic alteration in high-grade serous ovarian cancer (HGSOC). The impact of hotspot mutations of TP53 and protein levels on patient outcomes in HGSOC has not been fully elucidated.

Methods

The study population (n = 791) comprised of HGSOC samples with TP53 mutation from TCGA and other publicly available data. Univariate and multivariate cox proportional hazards regression analyses were used to select variables that were correlated with patient survival.

Results

We assessed the effects of TP53 mutations based on type and individual hotspot mutations on patient outcomes in HGSOC. Only hotspot mutations were associated with outcomes. Three hotspot mutations: G266, Y163C, and R282, in aggregate were associated with a wors

SUBMITTER: Tuna M 

PROVIDER: S-EPMC7000721 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature