Blood platelets stimulate cancer extravasation through TGFβ-mediated downregulation of PRH/HHEX.

ABSTRACT: Cancer cells go through a process known as epithelial-mesenchymal transition (EMT) during which they acquire the ability to migrate and invade extracellular matrix. Some cells also acquire the ability to move across a layer of endothelial cells to enter and exit the bloodstream; intra- and extravasation, respectively. The transcription factor PRH/HHEX (proline-rich homeodomain/haematopoietically expressed homeobox) controls cell proliferation and cell migration/invasion in a range of cell types. Our previous work showed that PRH activity is downregulated in prostate cancer cells owing to increased inhibitory PRH phosphorylation and that this increases cell proliferation and invasion. PRH inhibits migration and invasion by prostate and breast epithelial cells in part by activating the trans

SUBMITTER: Marcolino E 

PROVIDER: S-EPMC7000753 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature