Measured GFR by Utilizing Population Pharmacokinetic Methods to Determine Iohexol Clearance.

ABSTRACT:

Introduction

There is an increasing demand for accurately measured glomerular filtration rate (GFR). Iohexol serum clearance has become a new gold standard, but it is challenging when GFR is low and 24-hour sampling is required for accurate results. The primary aim of this study was to develop an iohexol pharmacokinetic population model for accurate determination of individual GFR using limited sampling for up to 5 hours also when renal function is <40 ml/min.

Methods

A nonparametric iohexol population pharmacokinetic model was developed with rich data from 176 patients. In a validation cohort of 43 patients, a model-determined GFR (iohexol clearance) using different limited sampling strategies for up to 5 hours was compared with the strategy currently used in routine care,

SUBMITTER: Asberg A 

PROVIDER: S-EPMC7000849 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature