The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration.

ABSTRACT: Promoting axon regeneration in the central and peripheral nervous system is of clinical importance in neural injury and neurodegenerative diseases. Both pro- and antiregeneration factors are being identified. We previously reported that the Rtca mediated RNA repair/splicing pathway restricts axon regeneration by inhibiting the nonconventional splicing of Xbp1 mRNA under cellular stress. However, the downstream effectors remain unknown. Here, through transcriptome profiling, we show that the tubulin polymerization-promoting protein (TPPP) ringmaker/ringer is dramatically increased in Rtca-deficient Drosophila sensory neurons, which is dependent on Xbp1. Ringer is expressed in sensory neurons before and after injury, and is cell-autonomously required for axon regeneration. Whil

SUBMITTER: Vargas EJM 

PROVIDER: S-EPMC7000917 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature