Bridging the Molecular-Cellular Gap in Understanding Ion Channel Clustering.

ABSTRACT: The clustering of many voltage-dependent ion channel molecules at unique neuronal membrane sites such as axon initial segments, nodes of Ranvier, or the post-synaptic density, is an active process mediated by the interaction of ion channels with scaffold proteins and is of immense importance for electrical signaling. Growing evidence indicates that the density of ion channels at such membrane sites may affect action potential conduction properties and synaptic transmission. However, despite the emerging importance of ion channel density for electrical signaling, how ion channel-scaffold protein molecular interactions lead to cellular ion channel clustering, and how this process is regulated are largely unknown. In this review, we emphasize that voltage-dependent ion channel density at nati

SUBMITTER: Nirenberg VA 

PROVIDER: S-EPMC7000920 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature