Clinicopathologic and prognostic significance of LGR5, a cancer stem cell marker in patients with colorectal cancer.

ABSTRACT:

Aim

To analyze the clinicopathologic and prognostic significance of Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), a cancer stem cell marker expression in a cohort of colorectal cancer patients (CRC).

Patients & methods

A total of 76 formalin-fixed paraffin-embedded tissue blocks of primary or metastatic tumors from 49 CRC patients were collected for duration 2009-2015. LGR5 expression was assessed through immunohistochemical staining of a tissue microarray.

Results

LGR5 was significantly over expressed in CRC tissue samples and found to be a statistically significant independent prognostic marker for an improved overall survival.

Conclusion

LGR5 expression was higher in colorectal cancer than in normal tissue. LGR5 was an independent progn

SUBMITTER: Ihemelandu C 

PROVIDER: S-EPMC7000925 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature