LANA and hnRNP A1 Regulate the Translation of LANA mRNA through G-Quadruplexes.

ABSTRACT: During the latent phase, Kaposi's sarcoma-associated herpes virus (KSHV) maintains itself inside the host by escaping the host immune surveillance mechanism through restricted protein expression. Latency-associated nuclear antigen (LANA), the most abundantly expressed protein, is essential for viral persistence, as it plays important roles in latent viral DNA replication and efficient segregation of the viral genome to the daughter cells following cell division. KSHV evades immune detection by maintaining the levels of LANA protein below a threshold required for detection by the host immune system but sufficient to maintain the viral genome. LANA achieves this by controlling its expression through regulation of its promoters and by inhibiting its presentation through interaction with the p

SUBMITTER: Dabral P 

PROVIDER: S-EPMC7000962 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature