Impact of Antiretroviral Therapy Duration on HIV-1 Infection of T Cells within Anatomic Sites.

ABSTRACT: Understanding the impact of antiretroviral therapy (ART) duration on HIV-infected cells is critical for developing successful curative strategies. To address this issue, we conducted a cross-sectional/inter-participant genetic characterization of HIV-1 RNA from pre- and on-therapy plasmas and HIV-1 DNA from CD4⁺ T cell subsets derived from peripheral blood (PB), lymph node (LN), and gut tissues of 26 participants after 3 to 17.8 years of ART. Our studies revealed in four acute/early participants who had paired PB and LN samples a substantial reduction in the proportion of HIV-infected cells per year on therapy within the LN. Extrapolation to all 12 acute/early participants estimated a much smaller reduction in the proportion of HIV-1-infected cells within LNs per year on therapy

SUBMITTER: Lee E 

PROVIDER: S-EPMC7000983 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature