Radiotherapy for geriatric head-and-neck cancer patients: what is the value of standard treatment in the elderly?

ABSTRACT: BACKGROUND:Head-and-neck squamous cell carcinoma (HNSCC) is one of the most common malignancies globally, and the number of elderly patients diagnosed with HNSCC is increasing. However, as elderly HNSCC patients are underrepresented in clinical trials, current clinical decision making for this cohort largely lacks clinical evidence. METHODS:Elderly patients (≥65 years) with HNSCC undergoing (chemo)radiotherapy from 2010 to 2018 at Freiburg University Medical Center were assessed for patterns of care, locoregional control (LRC), progression-free (PFS) and overall survival (OS) regarding definitive and adjuvant treatments. Acute and late therapy-associated toxicities were quantified according to CTCAE v5.0. RESULTS:Two hundred forty-six patients were included in this analysis, of whom 166 re

SUBMITTER: Haehl E 

PROVIDER: S-EPMC7001207 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature