PfSWIB, a potential chromatin regulator for var gene regulation and parasite development in Plasmodium falciparum.

ABSTRACT:

Background

Various transcription factors are involved in the process of mutually exclusive expression and clonal variation of the Plasmodium multigene (var) family. Recent studies revealed that a P. falciparum SWI/SNF-related matrix-associated actin-dependent regulator of chromatin (PfSWIB) might trigger stage-specific programmed cell death (PCD), and was not only crucial for the survival and development of parasite, but also had profound effects on the parasite by interacting with other unknown proteins. However, it remains unclear whether PfSIWB is involved in transcriptional regulation of this virulence gene and its functional properties.

Methods

A conditional knockdown system "PfSWIB-FKBP-LID" was introduced to the parasite clone 3D7, and an integrated parasite line "PfS

SUBMITTER: Wang WF 

PROVIDER: S-EPMC7001229 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature