IRGS: an immune-related gene classifier for lung adenocarcinoma prognosis.

ABSTRACT:

Background

Tumour cells interfere with normal immune functions by affecting the expression of some immune-related genes, which play roles in the prognosis of cancer patients. In recent years, immunotherapy for tumours has been widely studied, but a practical prognostic model based on immune-related genes in lung adenocarcinoma comparable to existing model has not been established and reported.

Methods

We first obtained publicly accessible lung adenocarcinoma RNA expression data from The Cancer Genome Atlas (TCGA) for differential gene expression analysis and then filtered immune-related genes based on the ImmPort database. By using the lasso algorithm and multivariate Cox Proportional-Hazards (CoxPH) regression analysis, we identified candidate genes for model development an

SUBMITTER: Shi X 

PROVIDER: S-EPMC7001261 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature