Inflexibility of the plasma miRNA response following a high-carbohydrate meal in overweight insulin-resistant women.

ABSTRACT:

Context

Metabolic inflexibility is a characteristic of insulin resistance, limiting the ability to transiently regulate oxidative metabolism and gene expression in response to nutrient availability. Little is known of the flexibility of post-transcriptional regulation, including circulatory miRNAs (c-miRNAs).

Design

The abundances of targeted c-miRNAs, with reported functions in metabolic regulation, were analysed in response to a high-carbohydrate meal in healthy weight insulin-sensitive (IS) and overweight insulin-resistant (IR) women.

Participants

Age-matched healthy weight IS (n = 20, BMI = 24.3 ± 0.70) and overweight IR (n = 20, BMI = 28.6 ± 0.67) women.

Methods

An abundance of c-miRNAs was quantified prior to and following a high-carbohydrat

SUBMITTER: Ramzan F 

PROVIDER: S-EPMC7001289 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature