Identification of E2 with improved secretion and immunogenicity against CSFV in piglets.

ABSTRACT:

Background

Outbreaks of Classical swine fever virus (CSFV) cause significant economic losses in the swine industry. Vaccination is the major method to prevent and control the disease. As live attenuated vaccines fail to elicit differentiable immunity between infected and vaccinated animals, subunit vaccine was considered as an alternative candidate to prevent and eradicate CSFV. Subunit vaccines present advantages in DIVA immunogenicity and safety. The technology was limited due to the low yield and the high cost with multiple and large doses. The native E2 signal peptide has not been well defined before. Here, the aim of this study is to develop a cost-effective and efficacious E2 vaccine candidate against CSFV with signal peptide and E2 sequence selection.

Results

A novel

SUBMITTER: Xu H 

PROVIDER: S-EPMC7001342 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature