A decrease in brown adipose tissue activity is associated with weight gain during chemotherapy in early breast cancer patients.

ABSTRACT:

Background

A decrease in thermogenesis is suspected to be implicated in the energy expenditure reduction during breast cancer treatment. This study aimed to investigate the impact of chemotherapy on the metabolic activity of brown adipose tissue (BAT) and the link with weight variation.

Methods

This was an ancillary analysis of a multicentre trial involving 109 HER2+ breast cancer patients treated with neoadjuvant chemotherapy. A centralised review of ¹⁸F-FDG uptake intensity (SUV_max) in specific BAT regions (cervical and supraclavicular) was conducted on two PET-CT scans for each patient (before and after the first course of chemotherapy).

Results

Overall, after one course of chemotherapy a significant decrease of 4.4% in ¹⁸F-FDG-upta

SUBMITTER: Ginzac A 

PROVIDER: S-EPMC7001369 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature