Diabetes does not increase infection risk or mortality following an infection in patients with cirrhosis and ascites.

ABSTRACT: Both cirrhosis and diabetes are established risk factors for infections. However, it remains uncertain whether diabetes adds to the risk of infections in patients with cirrhosis who are already at high risk of infections, or increases the mortality following an infection. To answer these questions, we followed a cohort of trial participants with cirrhosis and ascites for 1 year to compare the incidence of infections and post-infection mortality between those with or without diabetes.

Methods

We used Cox regression to estimate the hazard ratio (HR) of any infection, adjusting for confounding by patient age, gender, MELD score, albumin, use of proton pump inhibitors and lactulose, cirrhosis aetiology, and severity of ascites. Further, we analysed the mortality after infection.

Resu

SUBMITTER: Bossen L 

PROVIDER: S-EPMC7001534 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature