Spleen stiffness to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications.

ABSTRACT:

Background & aims

Both liver stiffness (LS) and spleen stiffness (SS) are widely used to non-invasively assess liver fibrosis and portal hypertension, respectively. We aimed to identify the impact of disease etiology, namely the localization of inflammation (portal vs. lobular), on the SS/LS ratio.

Methods

In this multicenter study, LS and SS were prospectively assessed in 411 patients with alcohol-related liver disease (ALD) or hepatitis C virus (HCV) using FibroScan® (Echosens, Paris); changes in these parameters were also studied in response to treatment (alcohol withdrawal, HCV therapy). LS and spleen length (SL) were further analyzed in a retrospective cohort of 449 patients with long-term data on decompensation/death.

Results

Both, SS and SL were signific

SUBMITTER: Elshaarawy O 

PROVIDER: S-EPMC7001583 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature