Elastase-triggered H₂S delivery from polymer hydrogels.

ABSTRACT: We report an elastase-responsive, H2S-releasing hydrogel prepared by covalently crosslinking a mixture of carboxymethylcellulose and poly(ethylene glycol) with an elastase-degradable peptide functionalized with an H2S-releasing S-aroylthiooxime (SATO) unit. Addition of elastase triggered a gel-to-sol transition, which exposed SATOs, leading to more and longer H2S release compared to untriggered gels.

SUBMITTER: Zhou M 

PROVIDER: S-EPMC7001589 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature