Engineered Cell-Derived Microparticles Bi₂Se₃/DOX@MPs for Imaging Guided Synergistic Photothermal/Low-Dose Chemotherapy of Cancer.

ABSTRACT: Cell-derived microparticles, which are recognized as nanosized phospholipid bilayer membrane vesicles, have exhibited great potential to serve as drug delivery systems in cancer therapy. However, for the purpose of comprehensive therapy, microparticles decorated with multiple therapeutic components are needed, but effective engineering strategies are limited and still remain enormous challenges. Herein, Bi₂Se₃ nanodots and doxorubicin hydrochloride (DOX) co-embedded tumor cell-derived microparticles (Bi₂Se₃/DOX@MPs) are successfully constructed through ultraviolet light irradiation-induced budding of parent cells which are preloaded with Bi₂Se₃ nanodots and DOX via electroporation. The multifunctional microparticles are obta

SUBMITTER: Wang D 

PROVIDER: S-EPMC7001653 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature