Body Composition, IGF1 Status, and Physical Functionality in Nonagenarians: Implications for Osteosarcopenia.

ABSTRACT:

Objectives

Body composition alterations occur during aging. The purpose of the present analysis was to explore the functional consequences of the overlap of sarcopenia and osteoporosis, and the potential role of insulin-like growth factor 1 (IGF1) in their development in the oldest old.

Setting and participants

Eighty-seven nonagenarians from the Louisiana Healthy Aging Study were included.

Measures

The definition of sarcopenia was based on appendicular lean mass (ALM). Osteoporosis was diagnosed based on bone mineral density (BMD) T score. Four phenotypes were compared: (1) healthy body composition, that is, nonosteoporotic nonsarcopenic (CO, control group), (2) osteoporotic (O, low BMD T score), (3) sarcopenic (S, low ALM), and (4) osteosarcopenic (OS, low BMD T sco

SUBMITTER: Poggiogalle E 

PROVIDER: S-EPMC7001873 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature