Figure 1 Theory Meets Figure 2 Experiments in the Study of Gene Expression.

ABSTRACT: It is tempting to believe that we now own the genome. The ability to read and rewrite it at will has ushered in a stunning period in the history of science. Nonetheless, there is an Achilles' heel exposed by all of the genomic data that has accrued: We still do not know how to interpret them. Many genes are subject to sophisticated programs of transcriptional regulation, mediated by DNA sequences that harbor binding sites for transcription factors, which can up- or down-regulate gene expression depending upon environmental conditions. This gives rise to an input-output function describing how the level of expression depends upon the parameters of the regulated gene-for instance, on the number and type of binding sites in its regulatory sequence. In recent years, the ability to make precisi

SUBMITTER: Phillips R 

PROVIDER: S-EPMC7001876 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature