More than fishing for a cure: The promises and pitfalls of high throughput cancer cell line screens.

ABSTRACT: High-throughput screens in cancer cell lines (CCLs) have been used for decades to help researchers identify compounds with the potential to improve the treatment of cancer and, more recently, to identify genomic susceptibilities in cancer via genome-wide shRNA and CRISPR/Cas9 screens. Additionally, rich genomic and transcriptomic data of these CCLs has allowed researchers to pair this screening data with biological features, enabling efforts to identify biomarkers of treatment response and gene dependencies. In this paper, we review the major CCL screening efforts and the large datasets these screens have made available. We also assess the CCL screens collectively and include a resource with harmonized CCL and compound identifiers to facilitate comparisons across screens. The CCLs in these

SUBMITTER: Ling A 

PROVIDER: S-EPMC7001883 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature