ERAP1 polymorphisms interactions and their association with Behcet's disease susceptibly: Application of Model-Based Multifactor Dimension Reduction Algorithm (MB-MDR).

ABSTRACT:

Background

Behçet's disease (BD) is a chronic multi-systemic vasculitis with a considerable prevalence in Asian countries. There are many genes associated with a higher risk of developing BD, one of which is endoplasmic reticulum aminopeptidase-1 (ERAP1). In this study, we aimed to investigate the interactions of ERAP1 single nucleotide polymorphisms (SNPs) using a novel data mining method called Model-based multifactor dimensionality reduction (MB-MDR).

Methods

We have included 748 BD patients and 776 healthy controls. A peripheral blood sample was collected, and eleven SNPs were assessed. Furthermore, we have applied the MB-MDR method to evaluate the interactions of ERAP1 gene polymorphisms.

Results

The TT genotype of rs1065407 had a synergistic effect on BD suscept

SUBMITTER: Riahi P 

PROVIDER: S-EPMC7001967 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature