Hyaluronan deposition in islets may precede and direct the location of islet immune-cell infiltrates.

ABSTRACT:

Aims/hypothesis

Substantial deposition of the extracellular matrix component hyaluronan (HA) is characteristic of insulitis in overt type 1 diabetes. We investigated whether HA accumulation is detectable in islets early in disease pathogenesis and how this affects the development of insulitis and beta cell mass.

Methods

Pancreas tissue from 15 non-diabetic organ donors who were positive for islet autoantibodies (aAbs) and from 14 similarly aged aAb^- control donors were examined for the amount of islet HA staining and the presence of insulitis. The kinetics of HA deposition in islets, along with the onset and progression of insulitis and changes in beta cell mass, were investigated in BioBreeding DRLyp/Lyp rats (a model of spontaneous autoimmune diabetes) from 40 d

SUBMITTER: Bogdani M 

PROVIDER: S-EPMC7002022 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature