Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation.

ABSTRACT: Blood vessels are lined by endothelial cells engaged in distinct organ-specific functions but little is known about their characteristic gene expression profiles. RNA-Sequencing of the brain, lung, and heart endothelial translatome identified specific pathways, transporters and cell-surface markers expressed in the endothelium of each organ, which can be visualized at http://www.rehmanlab.org/ribo. We found that endothelial cells express genes typically found in the surrounding tissues such as synaptic vesicle genes in the brain endothelium and cardiac contractile genes in the heart endothelium. Complementary analysis of endothelial single cell RNA-Seq data identified the molecular signatures shared across the endothelial translatome and single cell transcriptomes. The tissue-specific hete

SUBMITTER: Jambusaria A 

PROVIDER: S-EPMC7002042 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature