Ontology highlight
ABSTRACT:
SUBMITTER: Akkaya M
PROVIDER: S-EPMC7002124 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Science advances 20200205 6
The acquisition of malaria immunity is both remarkably slow and unpredictable. At present, we know little about the malaria parasite genes that influence the host's ability to mount a protective immune response. Here, we show that a single-nucleotide polymorphism (SNP) resulting in a single amino acid change (S to F) in an ApiAP2 transcription factor in the rodent malaria parasite <i>Plasmodium berghei</i> (<i>Pb</i>) NK65 allowed infected mice to mount a T helper cell 1 (T<sub>H</sub>1)-type im ...[more]