Comprehensive Transcriptome Profiling of Cryptic <i>CBFA2T3-GLIS2</i> Fusion-Positive AML Defines Novel Therapeutic Options: A COG and TARGET Pediatric AML Study.

ABSTRACT:

Purpose

A cryptic inv(16)(p13.3q24.3) encoding the CBFA2T3-GLIS2 fusion is associated with poor outcome in infants with acute megakaryocytic leukemia. We aimed to broaden our understanding of the pathogenesis of this fusion through transcriptome profiling.

Experimental design

Available RNA from children and young adults with de novo acute myeloid leukemia (AML; N = 1,049) underwent transcriptome sequencing (mRNA and miRNA). Transcriptome profiles for those with the CBFA2T3-GLIS2 fusion (N = 24) and without (N = 1,025) were contrasted to define fusion-specific miRNAs, genes, and pathways. Clinical annotations defined distinct fusion-associated disease characteristics and outcomes.

Results

The CBFA2T3-GLIS2 fusion was res

SUBMITTER: Smith JL 

PROVIDER: S-EPMC7002196 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature