Colony-stimulating factor 1 and its receptor are new potential therapeutic targets for allergic asthma.

ABSTRACT:

Background

A new approach targeting aeroallergen sensing in the early events of mucosal immunity could have greater benefit. The CSF1-CSF1R pathway has a critical role in trafficking allergens to regional lymph nodes through activating dendritic cells. Intervention in this pathway could prevent allergen sensitization and subsequent Th2 allergic inflammation.

Objective

To examine the therapeutic effectiveness of CSF1 and CSF1R inhibition for blocking the dendritic cell function of sensing aeroallergens.

Methods

We adopted a model of chronic asthma induced by a panel of three naturally occurring allergens and novel delivery system of CSF1R inhibitor encapsulated nanoprobe.

Results

Selective depletion of CSF1 in airway epithelial cells abolished the production of

SUBMITTER: Moon HG 

PROVIDER: S-EPMC7002247 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature