Genome-Wide Association Study of Cryptosporidiosis in Infants Implicates PRKCA.

ABSTRACT: Diarrhea is a major cause of both morbidity and mortality worldwide, especially among young children. Cryptosporidiosis is a leading cause of diarrhea in children, particularly in South Asia and sub-Saharan Africa, where it is responsible for over 200,000 deaths per year. Beyond the initial clinical presentation of diarrhea, it is associated with long-term sequelae such as malnutrition and neurocognitive developmental deficits. Risk factors include poverty and overcrowding, and yet not all children with these risk factors and exposure are infected, nor do all infected children develop symptomatic disease. One potential risk factor to explain these differences is their human genome. To identify genetic variants associated with symptomatic cryptosporidiosis, we conducted a genome-wide associ

SUBMITTER: Wojcik GL 

PROVIDER: S-EPMC7002356 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature