Ontology highlight
ABSTRACT:
SUBMITTER: Bolouri H
PROVIDER: S-EPMC7002445 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Bolouri Hamid H Young Mary M Beilke Joshua J Johnson Rebecca R Fox Brian B Huang Lu L Santini Cristina Costa CC Hill Christopher Mark CM Vries Anne-Renee van der Vuurst de AVV Shannon Paul T PT Dervan Andrew A Sivakumar Pallavur P Trotter Matthew M Bassett Douglas D Ratushny Alexander A
Scientific reports 20200205 1
Failure to clear antigens causes CD8<sup>+</sup> T cells to become increasingly hypo-functional, a state known as exhaustion. We combined manually extracted information from published literature with gene expression data from diverse model systems to infer a set of molecular regulatory interactions that underpin exhaustion. Topological analysis and simulation modeling of the network suggests CD8<sup>+</sup> T cells undergo 2 major transitions in state following stimulation. The time cells spend ...[more]